What Are Advanced Glycation End Products (AGEs)?

Advanced glycation end products (AGEs) are harmful compounds formed when proteins or fats react with sugars during high-temperature cooking processes. This reaction, known as the Maillard reaction, gives browned food its appealing flavor and color but also generates AGEs, which have been linked to chronic diseases, inflammation, and oxidative stress in both humans and animals.

How Do AGEs Affect Your Dog’s Health?

When dogs consume a diet high in AGEs—such as dry kibble, which undergoes extreme heat processing (extrusion or baking)—they accumulate these compounds in their bodies. Research suggests that AGEs contribute to:

  • Chronic Inflammation – AGEs stimulate inflammatory pathways, potentially leading to joint issues, arthritis, and other inflammatory conditions.
  • Increased Oxidative Stress – These compounds produce free radicals, damaging cells and accelerating aging.
  • Insulin Resistance & Diabetes – High AGE intake can impair insulin function, increasing the risk of diabetes and metabolic disorders.
  • Kidney & Liver Strain – The body works hard to eliminate AGEs, but excessive intake can burden the kidneys and liver, potentially leading to organ dysfunction over time.

Why a Raw Diet Minimizes Exogenous AGEs

A raw diet—consisting of fresh, unprocessed meats, organs, bones, and fruits/vegetables—contains significantly fewer exogenous (consumed via the diet) AGEs because it avoids the high-heat cooking processes responsible for their formation. Benefits of feeding a raw diet include:

  • Lower AGE Exposure – Raw meat naturally contains minimal AGEs, reducing the dietary burden on your dog’s system.
  • Improved Digestion & Nutrient Absorption – Fresh, unprocessed food is easier to digest, allowing better utilization of essential nutrients.
  • Healthier Skin & Coat – A raw diet supports skin health and coat quality by providing unaltered proteins and healthy fats.
  • Reduced Inflammation – Without excessive AGEs triggering inflammatory responses, dogs may experience fewer joint problems and overall improved well-being.

Transitioning to a Raw Diet

If you're considering switching your dog to a raw diet, do so gradually to allow the digestive system to adjust. Start by introducing small amounts of raw meat alongside their regular food, increasing the proportion over time. Consulting with a canine nutritionist can help ensure a balanced raw diet tailored to your dog's needs.

Final Thoughts

While kibble is convenient, its high AGE content poses long-term health risks. A fresh, raw diet minimizes exposure to harmful compounds, supports overall well-being, and aligns with a dog’s natural dietary needs. Making the switch could lead to a healthier, happier, and longer life for your furry companion.

March 21, 2025 — Joshua Krieg